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Metformin
Biguanide
Biguanide. Decades of research on metabolic and longevity outcomes.
Metabolic researchLongevity
/ research index
The research base
Research Maturity
★★★★★
5/5 — Volume of studies
Evidence Strength
★★★★★
5/5 — Quality of evidence
Most-studied metabolic compound. Extensive longevity research.
/ mechanism of action
How it works
AMPK activation. Multiple pleiotropic effects.
/ research dosing
Common research protocols
Range
500-2000 mg/day
Frequency
1-2x daily with meals
Route
Oral
Cycle
Continuous
Research notes
Start at 500mg/day with dinner to manage GI adjustment. Titrate up over 4-8 weeks. Extended-release reduces GI side effects. Most common longevity research dose: 1000-1500mg/day.
References
FDA Glucophage labelPMID: 25527144 (MILES trial) →
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use
As a solo compound
Standard standalone.
/ side effects
What to know
Common: GI adjustment.
/ timeline
Realistic expectations
Long-term
/ recommendation
Where to buy Metformin
🏆Our pick for Metformin
AMP Peptides
1000mg · USA · Card / Crypto
- ✓Third-party tested (Janoshik)
- ✓COAs provided — Per-batch
- ✓Highest verification tier in stock
- ✓4.8★ community rating
Also solid
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FOR RESEARCH USE ONLY. Metformin is intended for laboratory research and not for human consumption.