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MK-677
Ibutamoren / Oral GH Secretagogue
Oral ghrelin mimetic. Stimulates GH and IGF-1 release.
GH researchSleep researchAppetite studies
/ research index
The research base
Research Maturity
★★★★☆
4/5 — Volume of studies
Evidence Strength
★★★★☆
4/5 — Quality of evidence
Multiple human trials. Strong GH/IGF-1 elevation data.
/ mechanism of action
How it works
Ghrelin receptor agonist. Active orally — unique among GH-related compounds.
/ research dosing
Common research protocols
Range
10-25 mg/day (most common: 12.5-25mg/day)
Frequency
Once daily, usually before bed
Route
Oral (capsule or solution)
Cycle
2-3 months on, 1 month off
Research notes
Oral GH secretagogue (ghrelin mimetic). Causes substantial appetite increase, water retention, and can elevate cortisol. Bedtime dosing common but causes vivid dreams in some. Blood sugar/insulin sensitivity should be monitored.
References
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use
As a solo compound
Effective standalone, especially for those preferring oral administration.
/ side effects
What to know
Common: increased appetite, water retention, mild lethargy.
/ timeline
Realistic expectations
2-4 weeks
/ recommendation
Where to buy MK-677
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FOR RESEARCH USE ONLY. MK-677 is intended for laboratory research and not for human consumption.