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Retatrutide (GLP-3)

Triple GLP-1/GIP/Glucagon Receptor Agonist

Next-generation triple receptor agonist. Phase 3 clinical research underway.

Metabolic researchWeight management studiesGlucose regulation
Best Price
at AMP Peptides
$114.68
$5.73/mg · 20mg
Buy at AMP Peptides
/ research index

The research base

Research Maturity
★★★★
4/5 — Volume of studies
Evidence Strength
★★★★
4/5 — Quality of evidence

Phase 2 human trials demonstrate exceptional metabolic effects. 99%+ purity verified across batches in research-grade product.

/ mechanism of action

How it works

Simultaneously activates GLP-1, GIP, and glucagon receptors. Triple-receptor synergy for metabolic optimization.

/ research dosing

Common research protocols

Range
2 → 4 → 6 → 8 → 12 mg/week (titration ladder)
Frequency
Once weekly subcutaneous
Route
Subcutaneous abdomen, thigh, or upper arm
Cycle
Start at 2mg/week × 4 weeks → escalate by 2-4mg every 4 weeks → maintenance at 8-12mg/week
Research notes

Phase 2 trials titrated 2 → 4 → 8 → 12 mg/week over 24 weeks. GI side effects (nausea, occasional vomiting) peak with each dose increase. Heart rate elevation ~3-7 bpm at higher doses. Slow titration is essential — rapid escalation causes significant GI distress.

References
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use

As a solo compound

Highly effective standalone compound. Triple-receptor agonism is its primary differentiator.

/ side effects

What to know

Common: GI adjustment, appetite reduction (intended effect). Well-tolerated in clinical trials.

/ timeline

Realistic expectations

Effects observed within 2-4 weeks; full metabolic adaptation 12+ weeks

/ deep dives

Long-form research articles

/ recommendation

Where to buy Retatrutide (GLP-3)

🏆Our pick for Retatrutide (GLP-3)
Valor Peptides
20mg · USA · Card / Crypto
  • Third-party tested (Janoshik)
  • COAs provided — Comprehensive
  • Highest verification tier in stock
  • 4.8★ community rating
$200.34$167.41
$8.37/mg
Buy at Valor Peptides
Also solid
Modern Research Peptides
20mg · $9.52/mg
$190.49
Buy →
AMP Peptides
20mg · $5.73/mg
$114.68
Buy →
RetaOneLabs
20mg · $8.46/mg
$169.20
Buy →
/ all listings

Full index, price per mg

AMP PeptidesBEST
4.8
Size
20mg
Price
$114.68
$/mg
$5.73
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Glow Aminos
4.5
Size
20mg
Price
$117.07
$/mg
$5.85
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AMC Essentials
4.6
Size
20mg
Price
$122.12
$/mg
$6.11
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Solyn Peptides
4.5
Size
20mg
Price
$141.20
$/mg
$7.06
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Peptira
4.6
Size
20mg
Price
$146.34
$/mg
$7.32
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Throne
4.7
Size
20mg
Price
$161.47
$/mg
$8.07
Out of stock
MDPackUSA
4.5
Size
20mg
Price
$163.85
$/mg
$8.19
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RefillPen
4.5
Size
20mg
Price
$166.52
$/mg
$8.33
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Valor Peptides
4.8
Size
20mg
Price
$167.41
$/mg
$8.37
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RetaOneLabs
4.7
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20mg
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$169.20
$/mg
$8.46
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Good Labs
4.7
Size
20mg
Price
$171.60
$/mg
$8.58
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Biocase Innovations
4.6
Size
10mg
Price
$87.63
$/mg
$8.76
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AMP Peptides
4.8
Size
10mg
Price
$93.89
$/mg
$9.39
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Modern Research Peptides
4.8
Size
20mg
Price
$190.49
$/mg
$9.52
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Throne
4.7
Size
10mg
Price
$95.97
$/mg
$9.60
Out of stock
Southern Aminos
4.6
Size
20mg
Price
$192.04
$/mg
$9.60
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Atomik Labz
4.7
Size
20mg
Price
$192.68
$/mg
$9.63
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Peppy
4.7
Size
20mg
Price
$202.55
$/mg
$10.13
Out of stock
MDPackUSA
4.5
Size
10mg
Price
$106.75
$/mg
$10.68
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Lab Sourced
4.7
Size
20mg
Price
$217.84
$/mg
$10.89
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Molecular Solutions
4.7
Size
20mg
Price
$234.04
$/mg
$11.70
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EZ Peptides
4.7
Size
10mg
Price
$117.05
$/mg
$11.71
Out of stock
Glacier Aminos
4.6
Size
20mg
Price
$238.95
$/mg
$11.95
Out of stock
Atomik Labz
4.7
Size
10mg
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$119.81
$/mg
$11.98
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RefillPen
4.5
Size
10mg
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$122.32
$/mg
$12.23
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Modified Aminos
4.5
Size
10mg
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$131.66
$/mg
$13.17
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Welli Labs
4.6
Size
20mg
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$267.36
$/mg
$13.37
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Double R Labs
4.7
Size
20mg
Price
$268.67
$/mg
$13.43
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Ion Peptide
4.6
Size
20mg
Price
$269.57
$/mg
$13.48
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Biocase Innovations
4.6
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20mg
Price
$271.59
$/mg
$13.58
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Omegamino
4.5
Size
20mg
Price
$273.00
$/mg
$13.65
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Welli Labs
4.6
Size
10mg
Price
$136.62
$/mg
$13.66
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EZ Peptides
4.7
Size
20mg
Price
$276.92
$/mg
$13.85
Out of stock
Throne
4.7
Size
5mg
Price
$69.51
$/mg
$13.90
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Double R Labs
4.7
Size
10mg
Price
$140.04
$/mg
$14.00
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Flawless Compounds
4.7
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20mg
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$280.66
$/mg
$14.03
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Renova Peptides
4.6
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20mg
Price
$281.52
$/mg
$14.08
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Purus Peptides
4.7
Size
20mg
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$284.65
$/mg
$14.23
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AlgoRX
4.7
Size
20mg
Price
$286.33
$/mg
$14.32
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Lab Sourced
4.7
Size
10mg
Price
$143.52
$/mg
$14.35
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Modified Aminos
4.5
Size
5mg
Price
$72.79
$/mg
$14.56
Out of stock
Modified Aminos
4.5
Size
20mg
Price
$292.55
$/mg
$14.63
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Glacier Aminos
4.6
Size
10mg
Price
$157.28
$/mg
$15.73
Out of stock
Ion Peptide
4.6
Size
10mg
Price
$157.72
$/mg
$15.77
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Molecular Solutions
4.7
Size
10mg
Price
$158.13
$/mg
$15.81
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Renova Peptides
4.6
Size
10mg
Price
$160.78
$/mg
$16.08
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AMC Essentials
4.6
Size
10mg
Price
$166.58
$/mg
$16.66
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Southern Aminos
4.6
Size
10mg
Price
$169.30
$/mg
$16.93
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RetaOneLabs
4.7
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10mg
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$176.51
$/mg
$17.65
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Solyn Peptides
4.5
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10mg
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$179.66
$/mg
$17.97
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AlgoRX
4.7
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10mg
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$180.98
$/mg
$18.10
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RefillPen
4.5
Size
5mg
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$91.60
$/mg
$18.32
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Flawless Compounds
4.7
Size
10mg
Price
$183.40
$/mg
$18.34
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Omegamino
4.5
Size
10mg
Price
$186.43
$/mg
$18.64
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Welli Labs
4.6
Size
5mg
Price
$94.68
$/mg
$18.94
Out of stock
Biocase Innovations
4.6
Size
5mg
Price
$96.90
$/mg
$19.38
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Double R Labs
4.7
Size
5mg
Price
$97.21
$/mg
$19.44
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Peptira
4.6
Size
10mg
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$196.57
$/mg
$19.66
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RetaOneLabs
4.7
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5mg
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$98.74
$/mg
$19.75
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Valor Peptides
4.8
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5mg
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$98.96
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$19.79
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Valor Peptides
4.8
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10mg
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$203.22
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$20.32
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Purus Peptides
4.7
Size
10mg
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$207.19
$/mg
$20.72
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Peppy
4.7
Size
10mg
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$212.88
$/mg
$21.29
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Glow Aminos
4.5
Size
10mg
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$213.12
$/mg
$21.31
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Glacier Aminos
4.6
Size
5mg
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$106.68
$/mg
$21.34
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Modern Research Peptides
4.8
Size
10mg
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$215.17
$/mg
$21.52
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MDPackUSA
4.5
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5mg
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$108.16
$/mg
$21.63
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Good Labs
4.7
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10mg
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$219.53
$/mg
$21.95
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Renova Peptides
4.6
Size
5mg
Price
$119.59
$/mg
$23.92
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AMP Peptides
4.8
Size
5mg
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$121.65
$/mg
$24.33
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Peppy
4.7
Size
5mg
Price
$122.71
$/mg
$24.54
Out of stock
AlgoRX
4.7
Size
5mg
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$123.34
$/mg
$24.67
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Solyn Peptides
4.5
Size
5mg
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$123.97
$/mg
$24.79
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Lab Sourced
4.7
Size
5mg
Price
$124.35
$/mg
$24.87
Out of stock
Molecular Solutions
4.7
Size
5mg
Price
$130.09
$/mg
$26.02
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Atomik Labz
4.7
Size
5mg
Price
$135.35
$/mg
$27.07
Out of stock
Omegamino
4.5
Size
5mg
Price
$136.86
$/mg
$27.37
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Glow Aminos
4.5
Size
5mg
Price
$140.10
$/mg
$28.02
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Modern Research Peptides
4.8
Size
5mg
Price
$146.72
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$29.34
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EZ Peptides
4.7
Size
5mg
Price
$147.51
$/mg
$29.50
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Southern Aminos
4.6
Size
5mg
Price
$149.43
$/mg
$29.89
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Flawless Compounds
4.7
Size
5mg
Price
$160.56
$/mg
$32.11
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Purus Peptides
4.7
Size
5mg
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$166.26
$/mg
$33.25
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Good Labs
4.7
Size
5mg
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$167.87
$/mg
$33.57
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Peptira
4.6
Size
5mg
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$176.06
$/mg
$35.21
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AMC Essentials
4.6
Size
5mg
Price
$177.43
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$35.49
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Ion Peptide
4.6
Size
5mg
Price
$181.19
$/mg
$36.24
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FOR RESEARCH USE ONLY. Retatrutide (GLP-3) is intended for laboratory research and not for human consumption.