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Retatrutide (GLP-3)

Triple GLP-1/GIP/Glucagon Receptor Agonist

Next-generation triple receptor agonist. Phase 3 clinical research underway.

Metabolic researchWeight management studiesGlucose regulation

For research use only · Not for human consumption

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/ research index

The research base

Research Maturity
★★★★★
5/5 — Volume of studies
Evidence Strength
★★★★★
5/5 — Quality of evidence

Phase 2 human trials demonstrate exceptional metabolic effects. 99%+ purity verified across batches in research-grade product.

/ mechanism of action

How it works

Simultaneously activates GLP-1, GIP, and glucagon receptors. Triple-receptor synergy for metabolic optimization.

/ research dosing

Common research protocols

Range
2 → 4 → 6 → 8 → 12 mg/week (titration ladder)
Frequency
Once weekly subcutaneous
Route
Subcutaneous abdomen, thigh, or upper arm
Cycle
Start at 2mg/week × 4 weeks → escalate by 2-4mg every 4 weeks → maintenance at 8-12mg/week
Research notes

Phase 2 trials titrated 2 → 4 → 8 → 12 mg/week over 24 weeks. GI side effects (nausea, occasional vomiting) peak with each dose increase. Heart rate elevation ~3-7 bpm at higher doses. Slow titration is essential — rapid escalation causes significant GI distress.

References
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use

As a solo compound

Highly effective standalone compound. Triple-receptor agonism is its primary differentiator.

/ side effects

What to know

Common: GI adjustment, appetite reduction (intended effect). Well-tolerated in clinical trials.

/ timeline

Realistic expectations

Effects observed within 2-4 weeks; full metabolic adaptation 12+ weeks

/ deep dives

Long-form research articles

FOR RESEARCH USE ONLY. Retatrutide (GLP-3) is intended for laboratory research and not for human consumption.