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Tirzepatide
Dual GLP-1/GIP Receptor Agonist
Dual receptor agonist. Outperforms semaglutide in head-to-head trials.
Metabolic researchWeight managementGlucose control
/ research index
The research base
Research Maturity
★★★★★
5/5 — Volume of studies
Evidence Strength
★★★★★
5/5 — Quality of evidence
FDA approved. Phase 3 trials show superior metabolic effects vs single-receptor agonists.
/ mechanism of action
How it works
Activates both GLP-1 and GIP receptors. Dual-pathway stimulation.
/ research dosing
Common research protocols
Range
2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg/week (FDA titration)
Frequency
Once weekly subcutaneous
Route
Subcutaneous abdomen, thigh, or upper arm
Cycle
Start 2.5mg/week × 4 weeks → escalate by 2.5mg every 4 weeks → maintenance at 10-15mg/week
Research notes
Standard FDA titration for Mounjaro/Zepbound. Same molecule, same dosing ladder. Each step held 4 weeks minimum. If missing dose: take if >72 hours until next dose; otherwise skip. Dual GLP-1/GIP agonist — typically better GI tolerance than retatrutide at equivalent weight-loss efficacy.
References
FDA Mounjaro labelSURPASS-1 NCT03954834SURMOUNT-1 NCT04184622
FOR RESEARCH USE ONLY. Doses listed are compiled from published research literature, FDA-approved drug labels, and well-documented research community practice. Not medical advice.
/ standalone use
As a solo compound
Highly effective alone. Dual-agonist mechanism is its key feature.
/ side effects
What to know
Common: GI adjustment. Well-tolerated overall.
/ timeline
Realistic expectations
Effects within 2-4 weeks
/ recommendation
Where to buy Tirzepatide
🏆Our pick for Tirzepatide
Modern Research Peptides
5mg · USA · Card / Crypto
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- ✓4.8★ community rating
Also solid
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FOR RESEARCH USE ONLY. Tirzepatide is intended for laboratory research and not for human consumption.